Overview

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks a computational associate to join in efforts to develop and apply cutting-edge genomic technologies to characterize genomic rearrangements in cancers and normal tissues, and better understand how errors in double strand break (DSB) repair result in these rearrangements. Projects include 1) identifying sequence features that influence the formation of genomic rearrangements based on data from thousands of tumors and matched normal samples, 2) applying sophisticated statistical approaches to determine relationships between the presense of specific rearrangements and genetic/pharmacologic vulnerabilities in cancer cell lines, and 3) developing new analysis methods for a novel experimental technique developed in our laboratory to identify subclonal rearrangements in tumor samples.This individual will contribute to a lively team...