We are seeking a highly motivated and talented PhD candidate to investigate how type 2 cytokines shape the development and function of the immune system.

Project Overview

Type 2 immunity plays a central role in host defence against parasites and toxins, while also driving prevalent immune-mediated diseases such as eosinophilic asthma. This arm of immunity is orchestrated by key cytokines, including IL-4, IL-5, and IL-13 - now major therapeutic targets of monoclonal antibody-based therapies.

Despite their clinical importance, how type 2 cytokines influence immune cell development and long-term function remains poorly understood. Emerging evidence suggests these cytokines actively shape hematopoiesis, including myelopoiesis and lymphopoiesis, thereby influencing immune responses at their origin.

This project aims to uncover fundamental mechanisms linking type 2 cytokine signalling to immune cell development, with potential implicatio...