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This project will study pressing issues in research ethics in the domain of pediatric oncology. Clinical research is essential to develop and improve treatments for children with cancer. At the same time, pediatric oncology research raises ethical issues. This project focuses on a number of pressing issues in this field.

First, for 10-15 % of children with B-cell acute lymphoblastic leukemia (B-ALL) CAR-T cell therapy is offered as a last resort. Its therapeutic potential could however increase if accepted as frontline/standard therapy, but this is currently considered ethically problematic if children have other options. Moreover, the subsidiarity requirement is often strictly interpreted (implying that adults or adolescents should be enrolled before younger children). The revised Declaration of Helsinki has widened possibilities for research with vulnerable populations, but it is not yet common practice to “drop the age”. You will perform a...