MD/DO - Hematology Oncology Physician Land of 10,000 lakes, and the Mall of America! The Community - Minneapolis, MN Minneapolis is the most populous city in Minnesota with an estimated population of 429,606. Minneapolis lies on both banks of the Mississippi River, just north of the river's confluence with the Minnesota River, and adjoins Saint Paul, the state's capital. With one of the nation's best park systems, the city is abundantly rich in water, with thirteen lakes, wetlands, the Mississippi River, creeks and waterfalls, many connected by parkways in the Grand Rounds National Scenic Byway. The city and surrounding region are the largest population and primary business center between Chicago and Seattle. Minneapolis was historically a marketplace for timber, became the flour milling capital of the world, and, to the present day, preserved its financial clout. Anchoring strong music and performing arts scenes, Minneapolis is home to both the Guthrie Theater and the First Avenue nig...