Open to applications from U.S. Citizens and foreign nationals

A postdoctoral position is available in the laboratory of Dr. Dana Graves, University of Pennsylvania, to study why diabetes disrupts fracture healing and to develop a new local therapeutic strategy to restore bone repair. This project builds on compelling data showing that lineage-specific deletion of FOXO1 in chondrocytes or osteoblasts fully rescues diabetes-impaired fracture healing, as measured by histology, microCT, and mechanical testing. We have also found that loss of primary cilia in these same skeletal lineages reproduces key features of diabetic fracture healing. Together, these findings point to a novel FOXO1–primary cilia axis as a central regulator of skeletal repair in diabetes.



The successful candidate will investigate how diabetes-driven FOXO1 activity suppresses ciliogenesis and regenerative signaling in chondrocytes and osteoblasts. The project will use conditional mouse models...