The earth’s daily rotation causes profound, yet repetitive, changes to environmental conditions. In response, species from prokaryotes to humans have evolved circadian clocks to drive anticipatory daily rhythms in biological processes ranging in magnitude from DNA replication to sleep-wake cycles. However, cellular, tissue and systemic circadian rhythms exhibit a generalised decay during the ageing process that may contribute to the development of aged-related diseases and onset of frailty. In the Circadian Rhythms and Ageing laboratory, we aim to determine why this detrimental decay occurs and ask how we can correct or exploit these changes. To do so, we apply cutting edge in vivo, in vitro and in silico tools to provide unique, clinically relevant perspectives on the ageing of the bodies circadian system.

Age is cancers primary risk factor and a significant determinant of how this often-devastating disease presents and prog...