Overview

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking an experienced and highly motivated Research Associate to join the Mitochondrial Biology and Therapy Group led by Dr. Temurkhan Ayupov. IOB combines basic and clinical research to advance the understanding of vision and its diseases and to develop new therapies for vision loss. The Mitochondrial Biology and Therapy Group investigates how mitochondrial dysfunction contributes to neurodegeneration and develops therapeutic strategies for these diseases, including the development of cell-type-targeted mitochondrial transfer therapies. To accelerate this work, we are establishing genome-wide CRISPR screening as a discovery platform to identify genes and pathways that govern donor mitochondria internalization and integration. In this role you will design, execute, and analyze pooled CRISPR knockout, activation, and interference screens to uncover novel therapeutic targets and contribute to th...