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Research Associate, Mitochondrial Therapy Translational Research

Company

The Biozentrum, University of Basel

Location

basel, basel city

Posted

July 06, 2026

Position Overview

Your position

  • Design and execute genome-wide CRISPR knockout, CRISPRa, and CRISPRi screens in mammalian cell models
  • Validate screening hits using arrayed CRISPR experiments and orthogonal func-tional assays in relevant disease models
  • Establish, optimize, and routinely perform cell-line generation workflows using mito-chondrial transfer in immortalized and primary cells
  • Generate and analyze NGS and RNA-seq data from primary tissues and cultured cells
  • Develop and optimize cell-type-targeted mitochondrial transfer approaches in rele-vant in vitro and ex vivo models
  • Independently design, perform, document, and interpret experiments in a rigorous and reproducible manner
  • Work closely with technical staff and help supervise research assistants while re-maining experimentally active
  • Contribute experimentally to translational documentation, regulatory preparation, and clinical protocol development

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