Singapore-MIT Alliance for Research and Technology Centre – Kent Ridge

The AMR IRG is an interdisciplinary community of biologists, engineers, and clinicians from MIT and Singapore, sharing a state‑of‑the‑art research facility and united by a commitment to providing a supportive intellectual environment where students and staff can learn, grow, and contribute to solving a pressing societal problem.

The objective is to develop and apply an integrated drug discovery platform for RNA‑modifying enzymes, focusing on identifying and advancing small‑molecule inhibitors with therapeutic potential. The project combines cell‑based compound screening, quantitative LC‑MS/MS analysis of RNA modifications, target engagement assessment, and disease‑relevant validation to enable systematic discovery of drug candidates, pharmacodynamic biomarkers, and actionable RNA modification pathways for future therapeutic development.