We are a team headed by Dr Matias I Autio, Senior Scientist in the Laboratory of Systems Biology & Data Analytics.

We are embarking on an STDR funded proof‑of‑concept project to establish a method for generating genome‑engineered induced pluripotent stem cells for use in cell therapy. The project is closely linked with industrial partners and the aim is to translate the results eventually into the clinic.

We are looking for a Post‑Doctoral Fellow to drive the research activities for the duration of the project.

The next generation of cell therapies will utilize targeted integration of therapeutic payload transgenes into the genome of the cells. For disease indications where the engineered therapeutic cells require large or multiple payload transgenes, successful transgene integration poses drastic challenges. These challenges include, for example efficiency, random integration of transgenes and off‑target effects. T...